What is Cialis?

Cialis is a brand-name prescription medication used to treat erectile dysfunction (ED). The medication includes tadalafil as its active component, which is categorized as a phosphodiesterase type 5 (PDE5) inhibitor.

Cialis functions by enhancing the blood flow to the penis. When sexually stimulated, the increased blood flow helps achieve and maintain an erection. Here You can buy Cialis online overnight with same-day delivery. Cialis is available as a tablet that is taken by mouth. It comes in different doses ranging from 2.5 mg to 20 mg.

Cialis was originally developed by GlaxoSmithKline and approved by the U.S. Food and Drug Administration (FDA) in 2003. It is now owned, marketed, and distributed by Eli Lilly and Company.

Cialis is often referred to as “the weekend pill” because its effects can last up to 36 hours, which is longer than other ED medications. This allows for more spontaneity in sexual activity. The long duration of action also allows men to take Cialis once daily in a low dose for continuous treatment of ED.

How Does Cialis Work?

Cialis contains the active ingredient tadalafil, which is a PDE5 inhibitor. PDE5 (phosphodiesterase type 5) is an enzyme that regulates blood flow in the tissues of the penis. When sexually stimulated, nerves release nitric oxide which activates the enzyme guanylate cyclase, leading to increased levels of cyclic guanosine monophosphate (cGMP). The cGMP causes smooth muscle relaxation and increased blood flow into the spongy tissue of the penis, resulting in an erection.

PDE5 breaks down cGMP, which causes the erection to subside after ejaculation. By inhibiting PDE5, tadalafil allows cGMP to build up in the penis. This greatly increases blood flow and allows a firm, long-lasting erection to occur with sexual stimulation.

The effect of tadalafil may last up to 36 hours, which has led to Cialis being referred to as “the weekend pill.” This long duration of action allows more freedom in sexual activity without needing to plan around taking a pill. The onset of action is slower than other ED medications, taking 1-2 hours for full effect. Food does not impact absorption of tadalafil, providing another convenience factor.

Cialis Dosage

The recommended starting dose for Cialis is 10mg taken orally approximately 30 minutes before sexual activity. The 10mg dose can be taken as early as approximately 30 minutes before sex.

Based on effectiveness and side effects, the dose may be increased to 20mg or decreased to 5mg. The highest advised daily dosage is 20mg. Doses above 20mg per day have not been studied and are not recommended.

Cialis can be taken with or without food. Food does not affect its absorption or onset of action.

For daily use, the recommended starting dose is 2.5mg taken once per day at approximately the same time. Based on individual response, the dose can be increased to 5mg or decreased to 2.5mg. Do not exceed 5mg for daily use.

Cialis is also available in a 2.5mg or 5mg daily dose that is designed for daily use. The goal of this regimen is to provide continual treatment for erectile dysfunction, rather than just treating it on an as-needed basis.

How Long Does Cialis Last?

One of the unique qualities of Cialis that has distinguished it from competitors like Viagra is its long duration of action. While other ED medications typically last for only 4-5 hours, Cialis can work for up to 36 hours. This prolonged effect is why Cialis has sometimes been nicknamed “the weekend pill.”

After taking Cialis, clinical trials have shown you can achieve improved erections anytime between 30 minutes and 36 hours later. The median time is around 2 hours. This allows for a lot of flexibility on when sexual activity can occur.

The extended impact has advantages. It allows couples to be more spontaneous and engage in intercourse whenever desired over a day and a half. There is no need to precisely time taking the pill around when you anticipate having sex.

Side Effects Of Cialis

Cialis is generally well-tolerated, but some men do experience side effects. The most commonly reported side effects with Cialis include:

• Headache – This is the most common side effect, occurring in around 15% of men taking Cialis. The headaches are usually mild and tend to go away on their own within a few hours. Taking the medication with food can help minimize headaches.
• Indigestion – Around 7% of men report indigestion after taking Cialis. This side effect is likely due to the drug relaxing the muscles in the stomach. Eating a light meal before taking Cialis may help reduce indigestion.
• Back pain – Approximately 6% of men using Cialis experience back pain. This is often mild and tends to resolve within 12-24 hours. Proper lifting techniques and posture may help alleviate back discomfort.
• Muscle aches – About 5% of men report muscle aches and pains after using Cialis. The aches usually manifest within 12-24 hours after taking the drug but go away on their own within a couple of days. Staying hydrated and getting light exercise can minimize muscle soreness.

Most side effects are mild, and temporary, and tend to diminish with continued use. However, if any side effect is severe or persistent, contact your doctor. In rare cases, Cialis can cause more serious side effects like vision changes, hearing loss, or priapism (prolonged, painful erections).

Who Should Not Take Cialis?

Cialis is not suitable for everyone. Those with certain medical conditions or taking other medications may experience dangerous interactions and side effects if they take Cialis.

One important group that should avoid Cialis entirely is men who regularly use nitrate medications. Nitrates are most commonly used to treat angina (chest pain from heart disease). Common nitrate medications include:

• Nitroglycerin
• Isosorbide mononitrate
• Isosorbide dinitrate

When nitrates combine with Cialis in the bloodstream, they can cause a precipitous drop in blood pressure. This rapid blood pressure drop can be life-threatening. Men who regularly take nitrates for angina should never take Cialis or any other PDE5 inhibitor.

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