Drug Overview

Generic Name: Methadone

Brand Names: Methadose, Dolophine

Classification: Opioids, Narcotic Analgesics

What is Methadone?

Methadone is classified as an opioid drug, initially developed by German physicians during World War II. Initially prescribed in the United States for severe pain relief, it is now also utilized for treating heroin addiction and as a potent pain-relieving medication. This drug fundamentally alters the way the brain and nervous system respond to pain.

Methadone, a synthetic opioid agonist, interacts with the brain’s opioid receptors to diminish the urge for substances like heroin, morphine, and other opioid painkillers. Its effects typically begin within thirty minutes of ingestion, reaching peak effectiveness after three hours. The impact of Methadone can last for up to fifteen hours.

In the market, Methadone is sold under various brand names such as Methadone and Dolophine.

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Primary Uses of Methadone

• It is recommended for managing moderate to severe pain. 
• These medications are integrated into a comprehensive treatment plan for addiction. 
• It is employed to alleviate withdrawal symptoms resulting from the abrupt discontinuation of other opioids. 
• It addresses pain stemming from surgical procedures, injuries, or chronic illnesses. 
• They are administered before or after childbirth to manage labor pain.

How Does Methadone Work?

Methadone functions as a medication for drug dependence by decreasing the effects of various addictive medications such as Xanax (Alprazolam).

Moreover, Methadone affects pain perception by interacting with specific receptors in the brain. This mechanism alters how the nervous system and brain react to pain signals. Physicians may recommend this medication for patients experiencing severe pain from an injury, surgery, or chronic illness.

While there is an immediate response to this prescription, its full benefits may take up to five days to be realized.

Alone dose of Methadone offers relief from pain for six hours.

Warnings And Precautions Regarding Methadone

Before purchasing Methadone online, it is crucial to consider the following important warnings and precautions:

• Methadone usage has the potential to lead to addiction, abuse, and other adverse effects.
• Refrain from using Methadone if you suffer from severe respiratory conditions like asthma, or have intestinal or stomach blockages.
• Consult your physician if you are considering using Methadone during pregnancy, as withdrawal symptoms in unborn babies can have fatal consequences.
• It is strongly advised against combining Methadone with alcohol or other narcotics, as this can result in life-threatening overdose symptoms.

Avoid using Methadone while breastfeeding as it could impact your nursing baby through breast milk.

• Methadone has the potential to cause serious and even life-threatening respiratory depression. Be vigilant for signs of respiratory depression, particularly when initiating Methadone treatment or adjusting the dosage. Ingesting even a single accidental dose of Methadone, especially for children, can lead to a fatal overdose.
• Individuals with paralytic ileus should refrain from using Methadone. It is also not suitable for those with other gastrointestinal obstructions. 
• Methadone may trigger sphincter of Oddi spasms, so patients with biliary tract conditions, particularly acute pancreatitis, should be closely monitored for any worsening symptoms. Opioid use can raise serum amylase levels.
• Methadone could impair the mental and physical abilities required for tasks like driving or operating machinery that involve potential risks.

Dosing Information About Methadone

The amount of Methadone prescribed by your doctor will vary depending on factors like age, gender, the type of Methadone, and any other health issues you may have.

Typical adult dosage for pain:

• Starting dose: 20 to 30 mg (oral). An extra 5 mg or 10 mg may be administered after two to four hours if necessary.
• Maximum initial dose: 30 mg
• Maximum daily dose: 40 mg

Dosage for managing pain that falls within the moderate to severe range

In the form of a tablet

• For adults aged 18 and above: Take 2.5 mg of Methadone every 8-12 hours or as needed.
• For children under 18: It is not safe to administer Methadone to individuals under 18 years of age.

Dosage for opioid addiction detoxification

In the form of a tablet 

• For adults aged 18 and over Take 20 mg to 30 mg of the medication once daily or as needed.
• For children under 18: It is not safe to administer Methadone to individuals under 18 years of age.

Dosage to maintain opiate addiction

In the form of a tablet

Adults (18 years and older) should take 80 mg to 120 mg of the medication twice daily.

For children (under 18 years old) The use of Methadone may not be safe for treating patients under 18 years of age.

Side Effects of Methadone

Methadone may lead to both mild and severe side effects, even when used as directed.

Typical side effects of Methadone are:

• Drowsiness
• Dizziness
• Nausea and vomiting
• Increased sweating

The mentioned side effects are frequently occurring and usually do not necessitate medical intervention unless they become bothersome.

Nonetheless, it is recommended to discontinue Methadone usage and seek prompt medical advice if you encounter any of the following:

• Breathing difficulties or breathlessness during sleep
• Severe constipation
• Dizziness
• Rapid or irregular heartbeat
• Shortness of breath
• Fluttering sensation in the chest
• Decreased appetite
• Nausea or vomiting
• Fatigue or weakness
• Symptoms of serotonin syndrome like fever, hallucinations, muscle twitching, agitation, loss of coordination, etc.
• Any other serious allergic reaction to the medication

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